Ange Postecoglou are third in Group G, one point behind Real Betis and four Leverkusen leaders with two games to go.
But the Hoops will be sent to the Europa Conference League if they lose to the Bundesliga team and Betis beat Ferencvaros, who are bottom with four defeats out of four so far.
Celtic lost 4-0 to Leverkusen in September, and good results in Germany could ensure the Scottish Premiership team progresses and wins at home against Betis in the final.
Here’s all you need to know about this game before tonight.
When is Leverkusen vs Celtic?
The game kicks off at 5:45 pm GMT on Thursday 25 November.
How can I watch?
It will be broadcast live on BT Sport 3, with 5:15 p.m. BT Sport customers can also watch the game on the BT Sport page and mobile app.
What are team issues?
Celtic have no new injuries following their Scottish League Cup semi-final victory at St Johnstone on Saturday, but Tom Rogic, Carl Starfelt and Giorgos Giakoumakis were absent.
Bayer Leverkusen striker Patrick Schick is skeptical of those who have it, while Charles Aranguiz, Mitchel Bakker, Julian Baumgartlinger, Timothy Fosu-Mensah, Lucas Alario and Karim Bellarabi are all in doubt. Kerem Demirbay suspended.
Leverkusen: Hradecky; Frimpong, Tah, Tapsoba, Sinkgraven; Diaby, Andrich, Palacios, Wirtz, Amiri; Adli
Aselt: Hart, Ralston, Carter-Vickers, Welsh, Juranovic; Bitton, McGregor, Turnbull; Jota, Furuhashi, Abada
Celtic do not have a critical idea of the job at hand, but are in good shape and are hoping to take advantage of Leverkusen’s injury woes to find the most important point. Leverkusen 1-1 Celtic
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